Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Identifieur interne : 000801 ( Main/Exploration ); précédent : 000800; suivant : 000802Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Auteurs : Vincent A. Jourdain ; Nicolas Morin ; Laurent Grégoire ; Marc Morissette ; Thérèse Di PaoloSource :
- Journal of neurosurgery [ 1933-0693 ] ; 2015.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents (adverse effects), Basal Ganglia (metabolism), Disease Models, Animal, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (metabolism), Dyskinesia, Drug-Induced (surgery), Female, Levodopa (adverse effects), Macaca, Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (surgery), Receptors, Glutamate (metabolism), Subthalamic Nucleus (surgery).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , metabolism : Receptors, Glutamate.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug therapy : Parkinsonian Disorders.
- etiology : Dyskinesia, Drug-Induced.
- metabolism : Basal Ganglia, Dyskinesia, Drug-Induced, Parkinsonian Disorders.
- surgery : Dyskinesia, Drug-Induced, Parkinsonian Disorders, Subthalamic Nucleus.
- Animals, Disease Models, Animal, Female, Macaca.
Abstract
Unilateral subthalamotomy is a surgical procedure that may be used to alleviate disabling levodopa-induced dyskinesias (LIDs) in patients with Parkinson disease (PD). However, the mechanisms involved in LID remain largely unknown. The subthalamic nucleus (STN) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys.
DOI: 10.3171/2014.10.JNS141570
PubMed: 25932606
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000361
- to stream PubMed, to step Curation: 000361
- to stream PubMed, to step Checkpoint: 000361
- to stream Ncbi, to step Merge: 001B57
- to stream Ncbi, to step Curation: 001B57
- to stream Ncbi, to step Checkpoint: 001B57
- to stream Main, to step Merge: 000802
- to stream Main, to step Curation: 000801
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.</title><author><name sortKey="Jourdain, Vincent A" sort="Jourdain, Vincent A" uniqKey="Jourdain V" first="Vincent A" last="Jourdain">Vincent A. Jourdain</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morin, Nicolas" sort="Morin, Nicolas" uniqKey="Morin N" first="Nicolas" last="Morin">Nicolas Morin</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25932606</idno><idno type="pmid">25932606</idno><idno type="doi">10.3171/2014.10.JNS141570</idno><idno type="wicri:Area/PubMed/Corpus">000361</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000361</idno><idno type="wicri:Area/PubMed/Curation">000361</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000361</idno><idno type="wicri:Area/PubMed/Checkpoint">000361</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000361</idno><idno type="wicri:Area/Ncbi/Merge">001B57</idno><idno type="wicri:Area/Ncbi/Curation">001B57</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B57</idno><idno type="wicri:Area/Main/Merge">000802</idno><idno type="wicri:Area/Main/Curation">000801</idno><idno type="wicri:Area/Main/Exploration">000801</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.</title><author><name sortKey="Jourdain, Vincent A" sort="Jourdain, Vincent A" uniqKey="Jourdain V" first="Vincent A" last="Jourdain">Vincent A. Jourdain</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morin, Nicolas" sort="Morin, Nicolas" uniqKey="Morin N" first="Nicolas" last="Morin">Nicolas Morin</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of neurosurgery</title><idno type="eISSN">1933-0693</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Antiparkinson Agents (adverse effects)</term><term>Basal Ganglia (metabolism)</term><term>Disease Models, Animal</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (metabolism)</term><term>Dyskinesia, Drug-Induced (surgery)</term><term>Female</term><term>Levodopa (adverse effects)</term><term>Macaca</term><term>Parkinsonian Disorders (drug therapy)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (surgery)</term><term>Receptors, Glutamate (metabolism)</term><term>Subthalamic Nucleus (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Glutamate</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term><term>Dyskinesia, Drug-Induced</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinsonian Disorders</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Macaca</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unilateral subthalamotomy is a surgical procedure that may be used to alleviate disabling levodopa-induced dyskinesias (LIDs) in patients with Parkinson disease (PD). However, the mechanisms involved in LID remain largely unknown. The subthalamic nucleus (STN) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name><name sortKey="Jourdain, Vincent A" sort="Jourdain, Vincent A" uniqKey="Jourdain V" first="Vincent A" last="Jourdain">Vincent A. Jourdain</name><name sortKey="Morin, Nicolas" sort="Morin, Nicolas" uniqKey="Morin N" first="Nicolas" last="Morin">Nicolas Morin</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000801 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000801 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25932606
|texte= Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25932606" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |